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When pharmacologists refer to "synergism," they're almost uniformly talking about something bad. Medical synergism refers to two drugs that have similar negative effects which, when combined, produce a far more powerful effect than would be expected. In short, each drug exacerbates the problems associated with the other. Here two plus two can equal five — or 500.
Check it out at: http://www.citypaper.net/articles/2010/01/14/synergism
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